Fexofenadine hydrochloride is a second-generation antihistamine that works by blocking H2 receptors and is primarily indicated for allergic rhinitis. To satisfy the desired pharmacological effect it is important for a drug to comply with all the specifications of the guideline. This study has been conducted to evaluate the quality parameters of commercial drugs and establish a comparative screening of commercial drugs with the formulated ones. Fexofenadine HCl was formulated in the laboratory setup and one particular brand was selected and compared with the formulated drug. The quality parameter was checked by performing potency and dissolution test, weight variation test, thickness hardness-diameter determination, disintegration time detection and friability test. The test result has shown that formulated dug has a similar potency to the commercial drug with the commercial drug achieving a potency of 97.5%. The values obtained from the tests were used to analyze the degree of conformance of commercially available drugs to the USP specification that represents the quality of both commercially available and formulated fexofenadine hydrochloride 120 mg tablets. The results found in the experiment were used to find out the degree of compliance of the drugs to the USP specification which indicates the quality of Fexofenadine hydrochloride. All the parameters comply with the USP specifications which ensure the desired pharmacological effect.
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