Healthmed Journal of Pharmaceutical Sciences
An International, Open Access, Peer Reviewed Journal
ISSN: 3078-6975 (Online)
Impact of IRS1 (rs1801276) Gene Polymorphism on Type-2 Diabetes Mellitus in Bangladeshi Patients
Year : 2024 , Volume : 2, Issue : 2, Pages : 7-12
Original Research
Author :
Abstract
The aim of this study was to investigate the possible effect of the insulin receptor substrate 1 (IRS1) gene (rs1801276) polymorphism on type-2diabetes mellitus risk in Bangladeshi patients. Type-2 diabetes mellitus (T2DM) is a chronic metabolic condition defined by persistent hyperglycemia that is predominantly caused by hereditary and environmental factors. The IRS1 (rs1801276) polymorphism has been linked to changes in the transmission of insulin and glucose metabolism which contribute to the development of type-2 diabetes. A cross-sectional study was carried out on 200 type-2 diabetes patients and 200 healthy controls. Genomic DNA was taken from blood samples, and the rs1801276 polymorphism was detected using PCR-RFLP. Statistical analysis was conducted to determine the relationship between the IRS1 polymorphism and the prevalence of T2DM. To determine how the IRS1 gene has an impact on type-2 diabetes we studied 200 case patients and 200 control individuals. Our investigation indicates that the IRS1 gene polymorphism has no significant effect on the CG genotype [OR = 3.6283, 95% Cl = (0.7443 to 17.6860, P=0.1108], GG genotype [OR = 1.0366, 95% Cl =(0.0205 to 52.5059, P=0.9857] and the CG+GG genotype [OR = 3.6283, 95% Cl = (0.7443 to 17.6860, P=0.1108] compared with wild type CC genotype. The IRS1 (rs1801276) polymorphism is not significantly linked to Type-2 diabetes mellitus in Bangladeshi people. This finding emphasizes its potential for further studies with larger population to identify this polymorphism as a genetic marker for the diagnosis and treatment of T2DM patients in Bangladesh.
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