Healthmed Journal of Pharmaceutical Sciences

Analgesic, CNS Depressant and Antibacterial Activities of the Ethanol Extract of Spilanthes paniculata Leaves

Original Research

Author : Md. Khalequeuzzaman, Sadia Islam, Mst. Mahfuza Khatoon, Anik Kumar Dey,

Abstract

Spilanthes paniculata is an important medicinal plant which is used to treat toothache, throat and gum infections. The present study was aimed to investigate the analgesic, CNS depressant and antibacterial activities of the ethanol extract of Spilanthes paniculata leaves. Analgesic activity was determined by formalin and acetic acid induced writhing method. In acetic acid induced writhing method, the SPE showed significant writhing inhibition (p<0.01) 66.92% at a dose of 500mg/kg body weight as compared to standard drug indomethacin (60%; 10mg/kg body weight). In formalin test, the SPE showed a significant licking inhibition (p<0.01) 46.77% at a dose of 500mg/kg body weight as compared to standard drug indomethacin (37.10%; 10mg/kg body weight). In CNS depressant activity, test animals showed significant decrease (p<0.001) in number of movement in the dosages of 500mg/kg as compared to standard drug diazepam at a dose of 1mg/kg. In the anti-bacterial test against some gram positive and gram negative bacteria, it was found that the SPE showed moderate activity against most of the test organisms at a concentration of 800µg/disc. The above evidence suggest that ethanol extract of Spilanthes paniculata is a source of natural analgesic and CNS depressant along with moderate antibacterial activity.

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